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Title: Endothelin-converting enzymes, Aß and oxidative stress in Alzheimer's disease
Author: Tayler, Hannah Mary
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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Alzheimer's disease (AD) is thought to be initiated by the abnormal accumulation of Aß within the brain. Cerebrovascular dysfunction and cerebral hypoperfusion are central to the development vascular dementia (VaD) but are also thought to contribute to the progression of AD. A reduction in cerebral perfusion can be demonstrated prior to the onset of dementia in people who subsequently develop AD, and in patients with early disease the extent of reduction in perfusion predicts the rate of cognitive decline. In AD, there is also reported to be oxidative stress in the brain and it has been posited that this may serve as a pathogenic link between Aß, endothelial dysfunction and neuronal damage. Recent studies have also implicated the endotheJin pathway in the endothelial dysfunction in AD. In this pathway the production of endothelin-l (ET-1), a potent mediator of vasoconstriction, is catalysed by endothelin-converting enzyme (ECE)-1 in endothelial cells and ECE-2 in neurons. Both endothelin-converting enzymes are capable of degrading Aß and ECE-2 expression is upregulated by Aß.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available