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Title: New phosphorus chemistry in ionic liquids
Author: Crossley , Kerri
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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Organophosphorous compounds and their use as reagents have witnessed significant interest from researchers in recent years. This can be attributed to their vast array of applications industrially and synthetically. Phosphorodiamidites and their derivatives are of particular interest especially in relation to oligonucleotide synthesis. Additionally, they have been utilised as precursors to phosphonamidates which can be used as intermediates towards pyrophosphate analogues such as bisphosphonates. Unfortunately, the synthesis of phosphorodiamidites and their analogues, particularly on a large scale is hampered by their high instability to air and moisture as well as the instability of their synthetic precursor, phosphorus trichloride (PCh). The continued use of large quantities of organic solvents as liquid media for chemical reactions, coupled with high temperatures and pressures is a major concern in today's chemical industry. Ionic liquids are low volatility solvents which are being increasingly used as popular alternatives to molecular solvents. Ionic liquids based on the bis[trifluoromethyl)sulfonyl] imide (NTf2r anion provided a suitable environment for the novel one-pot synthesis of a series phosphorodiamidite and phosphoramidite reagents. In addition to providing a stable environment for the synthesis, the ionic liquids could be utilised as storage media for these reactive materials.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available