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Title: Synthesis of novel calix[4]arene based dendrimers and their biological applications
Author: Atzori, Simone
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2013
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This thesis describes the development and synthesis of multicalixarenes and their application in gene and drug delivery. Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two families of amino functionalised multicalixarenes are described. Evaluation of their toxicity and transfection studies are reported and a number of candidates for development identified. Chapter 2 describes the development of calixarene glycoconjugates using a wide range of approaches. The synthesis of calixarene glycoconjugates through click chemistry is reported and the development of the first multicalixarene glycoconjugate is discussed. Chapter 3 reviews the development of large multicalixarenes assemblies. The synthesis of large (9 and 21 member) click based multicalixarenes is described.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available