Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600345
Title: Controlled coating of nanoparticles with peptides and lanthanide complexes : a photophysical evaluation
Author: Savage, Alison Clare
ISNI:       0000 0004 5351 1138
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2014
Availability of Full Text:
Access through EThOS:
Full text unavailable from EThOS. Thesis embargoed until 31 Dec 2019
Access through Institution:
Abstract:
This thesis describes the co-coating of gold nanoparticles with different combinations of lanthanide complexes and peptides, and the effect of this co-coating on the photophysical properties of the lanthanide complexes has been examined. A photophysical study of europium (III) ions binding to two surface active peptides in solution is presented and the ability of these peptides to bind the europium ions whilst tethered to gold nanoparticles is discussed. Lanthanide complexes with a diethylenetriaminepentaacetic acid (DTPA) binding motif were prepared and attached to gold nanoparticles with different peptides to investigate their photophysical properties and their potential as a cellular imaging agent has been demonstrated. The co-coating of gold nanoparticles with europium and gadolinium complexes is also introduced, and these nanoparticles have the potential to be used as a multi-modal imaging agent for luminescent and magnetic resonance imaging. The synthesis of an azo-dye has been undertaken and its ability to bind and sensitise the near infrared lanthanides neodymium (III) and ytterbium (III) has been demonstrated. It was found to form complexes with these lanthanides, and the high molar absorption coefficients in the visible region allows for excitation at wavelengths up to 500 nm.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.600345  DOI: Not available
Keywords: QD Chemistry
Share: