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Title: Studies in glycosylation methodology
Author: Green, L.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 1998
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This thesis is divided into two sections. The first section covers techniques, strategies and mechanisms of oligosaccharide formation, illustrated with both literature and the author's results, highlighting the many subtleties involved in performing a glycosylation. These include attempts at trans-glycoside formation on a polymer support without the use of an acetyl directing group and the curious failure of an acetyl group to direct a glycosylation in the synthesis of a lactosamine derivative. The second section describes studies towards the development of stereocontrolled glycosylation protocol, based upon a intramolecular aglycon delivery strategy. Various tethers ranging from anomeric carbonates to anomeric phosphoranes were tried to realise this strategy but a solution remained elusive.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available