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Title: The relationship between neuronal electrical activity, cerebral metabolism and blood flow following brain injury
Author: Coleman, M. R.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2000
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The normal functioning and viability of the human brain is among other things, dependent upon a close relationship between neuronal electrical activity, metabolism and blood flow. The concept that there exists a tight association between these processes was first proposed by Roy and Sherrington over 100 years ago and has since been corroborated by many studies in humans and animals. In diseased states there is a large amount of evidence to suggest these variables are affected by the injury process. However, very little work has been conducted to determine what effect an insult to the brain has on the relationship between them. This thesis examines the effect of traumatic brain injury and subarachnoid haemorrhage on the relationship between neuronal electrical activity and metabolism (neurometabolic coupling), electrical activity and blood flow (neurovascular coupling) and, blood flow and metabolism (flow-metabolism coupling). These relationships were addressed using a multimodality approach, in which the electroencephalogram and somatosensory evoked potential were obtained during the same session as positron emission tomography. This approach provided a measure of neuronal electrical activity, cerebral metabolism and blood flow during resting conditions. It was found that these disease states have profound, but similar effects on the integrity of neurometabolic, neurovascular and flow-metabolism coupling. Disruption showed linear and non-linear behaviour, with severity and temporal specificity. It is concluded that these findings provide new insights into the pathophysiological consequences of brain injury with important implications for the interpretation of modern functional imaging as well as future therapeutic aims.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available