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Title: The effects of isoflavones on some risk factors for breast cancer, osteoporosis, and ischaemic heart disease
Author: Atkinson, C.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2000
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Abstract:
To investigate whether phytoestrogens had an antioestrogenic effect, a large double blind, randomised, placebo controlled trial was conducted for approximately one year. Mammographic breast density, hormone levels, menopausal symptoms, cardiovascular risk factors, bone density, and body composition were assessed. When compared with the effects of placebo, 40mg daily dose of isoflavones did not significantly alter mammographic breast density when assessed by several different methods. Mean change in estimated percent density determined from the mammogram comparison data was - 1.35% (SD 5.16) in the isoflavone group, and -1.79% (SD 7.41) in the placebo group. There was also no significant effect on levels of oestradiol, FSH, or LH. Menopausal symptoms, and hot flushes specifically, were not significantly altered by clover isoflavones. Cardiovascular risk factors (blood pressure, blood lipids, and blood clotting factors) were also not significantly altered. However, the isoflavones did affect bone density. Spine bone mineral density (BMD) decreased to a significantly lower extent in the isoflavone group compared with that seen in the placebo group (p<0.01). The effect on BMD was mainly seen in the pre- and peri-menopausal women, and isoflavones also had a significant effect on BMC in this group. Levels of the bone resorption marker, deoxypyridinoline (Dpd) increased in both the isoflavone and placebo pre- and peri-menopausal groups. However, the increase was significantly lower in the isoflavone group compared with placebo (p=0.03), supporting the finding of a beneficial effect of isoflavones on bone as judged by BMD and BMC. Similar trends (not significant) regarding BMC and BMD were seen in the hip in pre-and peri-menopausal women, and there was a significant increase in body fat with the isoflavone supplement in this group (p<0.01).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.596214  DOI: Not available
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