Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595572
Title: Reagent-free flow chemistry
Author: Bolien, David
ISNI:       0000 0004 5349 0728
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2014
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Abstract:
A range of flow chemistries unified by the overlapping concepts of Reagentless Synthesis and Reactive Intermediate Trapping were developed. Thermochemically-promoted transformations for the generation and trapping of reactive intermediates, such as ketenes and N-acyliminium species, are reported. A particular emphasis was given to acquire kinetic data by means of in-situ spectroscopy techniques. Photochemistry is another ‘reagentless’ technique that is much less used in organic synthesis than might be expected from its capabilities. Flow chemistry provides a timely opportunity to develop ‘user friendly’ photochemical flow reactors and validate the equipment on selected photochemical reactions. Organometallic compounds impose particular challenges when handled in flow. Homogeneous or immobilised cobalt reagents were tested in combination with commercial flow equipment. Flow syntheses of selected piano stool iron complexes are also presented. Finally mixing properties of simple-shaped commercial flow mixers were assessed due to their critical role in commercial flow platforms. A mixing test was developed and compared against established procedures.
Supervisor: Whitby, Richard Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.595572  DOI: Not available
Keywords: QD Chemistry
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