Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595013
Title: Synthetic polynucleotides and interferon induction
Author: Folayan, Joseph Ololade
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 1973
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Abstract:
Modified cytidylic and adenylic acids have been synthesised and studied as possible inducers of interferon when hybridised with the appropriate polynucleotides. The report in this thesis describes: a) The synthesis and characterisation of poly (5-fluorocytidylic acid) to complete the series of 5-halo substituted cytidylic acids. Poly(I). poly(fl⁵C) was interferon inducing. b) The synthesis and characterisation of poly (5-dimethylaminocytidylic acid) in which a substituent other than the halogens was inserted into the 5-postion of cytidine. The polymer formed a 1:1 hybrid with poly(I) and the hybrid was a good inducer of interferon. c) The synthesis and characterisation of poly (8-oxyadenylic acid) which was one of the first 8-substituted homopolymers of adenosine.
Supervisor: Not available Sponsor: Government of Nigeria
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.595013  DOI: Not available
Keywords: QD Chemistry
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