Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594563
Title: Generation and modulation of network oscillations on the rodent prefrontal cortex in vitro
Author: Glykos, Vasileios
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2013
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Abstract:
Fast network oscillations (~12-80 Hz) are recorded extensively in the mammalian cerebral cortex in vivo which local and distant neuronal populations orchestrate their firing activity to process cognitive-related information. The rat medial prefrontal cortex (mPFC) is considered to be functionally and anatomically homologous to the primate in vitro studies have demonstrated that the mPFC can sustain carbachol-induced persistent beta1 or kainate-induced transient low gamma frequency oscillations. We wished to establish an in vitro paradigm of carbachol (10 μM) / kainate (200 objective to investigate the distribution patterns and the mechanisms of these oscillations. Then we assessed the modulatory effects of the ascending catecholamine systems on fast network oscillations with exogenous application of Persistent fast network oscillations in the ventral mPFC were stronger, more rhythmic but slower (~25 Hz) than oscillations in the dorsal mPFC (~28 Hz). The regional difference in the oscillation amplitude was correlated to the strong regions in the mPFC, oscillations were stronger in layer 5. Oscillations relied on GABA, kainate but not AMPA receptors. In the ventral mPFC, network oscillations A were also dependent on NMDA receptor-mediated synaptic transmission. μM) reduced the oscillation strength and rhythmicity in the ventral mPFC. Instead, dopamine increased the power and rhythmicity of network oscillations in the dorsal mPFC. The region-dependent dopamine effect was correlated to the induced effects on synaptic inhibition and neuronal firing. μM) reduced the osc caused no effect on the dorsal mPFC.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.594563  DOI: Not available
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