Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592388
Title: The place of misoprostol in the evacuation of the human pregnant uterus
Author: El-Refaey, H. A.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1994
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Abstract:
This thesis evaluates the role, safety, and side effects of misoprostol in the evacuation of the pregnant uterus. Chapter 1 includes a discussion and literature review of the status of abortion practice in the world and the magnitude of the associated morbidity and mortality. The place of misoprostol among other prostaglandin agents, as well as its development, safety and applications are reviewed. The rationale and aims of the thesis are explained. Chapter 2 describes two open studies examining the place and applicability of misoprostol in the evacuation of the pregnant uterus in cases of miscarriage. The first study examines the place of misoprostol in the evacuation of the uterus in cases of anembryonic pregnancy and missed abortion in women pretreated with mifepristone. The second study describes the sole use of misoprostol in the management of incomplete abortions. Chapter 3 describes a randomised study examining the efficacy and side effects of two misoprostol dose regimens in the induction of abortion prior to 56 days amenorrhea in women pretreated with mifepristone. Chapter 4 examines the place of the vaginal administration of misoprostol to induce abortion in women prior to 63 days of amenorrhea and pretreated with mifepristone. Two studies are presented. The first is an open study examining this approach and the second is a randomised study evaluating the oral versus vaginal administration of the drug. Chapter 5 examines the place of misoprostol in the management of second trimester pregnancy. Two randomised studies are described. They evaluate different regimens of misoprostol when administered orally and vaginally after mifepristone treatment. Chapter 6 assesses the place of misoprostal as a cervical priming agent prior to surgical termination of pregnancy. A randomised study evaluating the biophysical and histochemical changes induced in the cervix is described.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.592388  DOI: Not available
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