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Title: Digital signal processing techniques for gene prediction
Author: Papaspiridis, Alexandros
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2012
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The purpose of this research is to apply existing Digital Signal Processing techniques to DNA sequences, with the objective of developing improved methods for gene prediction. Sections of DNA sequences are analyzed in the frequency domain and frequency components that distinguish intron regions are identified (21t/lOA). Novel detectors are created using digital filters and auto correlation, capable of identifying the location of intron regions in a sequence. The resulting signal from these detectors is used as a dynamic threshold in existing gene detectors, resulting in an improved accuracy of 12% and 25% respectively. Finally, DNA sequences are analyzed in terms of their amino acid composition, and new gene prediction algorithms are introduced.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available