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Title: A clinical and genetic study of deafness and hearing loss in Oman
Author: Al-Khabouri, Mazin Jawad Jafar
Awarding Body: St George's, University of London
Current Institution: St George's, University of London
Date of Award: 2012
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Abstract:
A community-based nationwide survey for hearing loss was conducted in Oman in between 1996 and 1997. Audiometric tests and ear examinations were conducted for 12,400 persons in phase I. In phase 11, otologists examined the hearing-impaired subjects to determine the cause. The prevalence of bilateral hearing impairment was 55/1000 (95% Cl 51.08-59.47). The prevalence of bilateral disabling hearing loss was 2111000 (95% Cl 18.07-23.29). Register of Omani paediatric cases with severe to profound deafness: The study includes a retrospective analysis of causes of deafness in 1400 Omani children who were detected to be suffering frorri severe to profound levels of hearing impairment. A standard form was used to collect various details from the otolaryngologists all over the country. The time period included is from 1986 to 2000. The rate of consanguineous marriage in the parents of the affected children was 70%, and 67.8% of these children had a sibling suffering from hearing impairment. Consanguinity and deafness in the Omani paediatric population: It was found that 70% of the deaf children were from parents of consanguineous marriages, and 30% from non-consanguineous unions. In those with consanguineous families 70.2% were first cousin marriages, 17.5% were second cousins, and 10.9% were from the same tribe. The 14 • proportion arising from first cousin marriages was higher than the background rate of first cousin marriages in Oman. Study to look for the GJB2 gene mutation in Omani population: This study was done using both PCR-RFLP and direct DNA sequencing methods. Two common GJB2 gene mutations (35de1G and 167de1T) were screened in 280 healthy controls and 95 deaf patients using two different PCR-RFLP methods. None of the samples studied, either by RFLP or sequencing, revealed any deafness-associated mutations in the coding region of the GJB2 gene. 15 •
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.590024  DOI: Not available
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