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Title: The role of metal ions and reactive oxygen species in Beta - amyloid aggregation and toxicity and their relevance to Alzheimer's disease
Author: Mayes, Jennifer Helen
Awarding Body: Lancaster University
Current Institution: Lancaster University
Date of Award: 2010
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The aggregation and deposition of ß-amyloid (Aß) in the brain has long been implicated in the neurotoxic pathways causing Alzheimer's disease (AD). Recent data suggests that early, soluble oligomers of Aß are the toxic species. Oxidative stress may be partly responsible for the toxicity of the peptide as hydrogen peroxide (H2O2)has been found to be produced during the early stages of aggregation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available