Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585121
Title: Gamma-synucleinopathy in mice (and humans?)
Author: Peters, Owen
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
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Abstract:
As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.585121  DOI: Not available
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