Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585099
Title: Investigating the mechanistic basis of telomeric fusions
Author: Heppel, Nicole H.
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
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Abstract:
Furthermore, NBS1 deficiency results in a paucity of sporadic telomere deletion events which is consistent with the hypothesis that NBS1 is involved in the resolution of Holiday junctions within T-loops creating telomeric deletion events. In contrast, DNA Ligase IV deficiency and PARP1 inhibition caused distinct short telomere length distributions. Both these phenotypes might be related to problems with telomere replication.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.585099  DOI: Not available
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