Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.584942
Title: Desymmetrisation reactions of cyclohexa-1,4-dienes and marine natural product synthesis
Author: Hill-Cousins, Joe
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2010
Availability of Full Text:
Access through EThOS:
Access through Institution:
Abstract:
This thesis describes novel diastereoselective group selective processes for the desymmetrisation of cyclohexa-1,4-dienes, and their application to target synthesis of the cladiellin diterpenes. In addition, an enantioselective approach to batzelladine C methyl ester is described, permitting stereochemical assignment of batzelladine C. Chapter 1 describes the use of diastereoselective iodocyclisation reactions for the desymmetrisation of cyclohexa-1,4-dienes, and also details a novel epoxidation-cyclisation transformation, enabling the formation of up to six contiguous stereogenic centres, selectively, in a single step. Chapter 2 introduces the cladiellin diterpenes and describes the application of novel diastereoselective Prins chemistry for the synthesis of a model of the cladiellin core. Chapter 3 describes our attempts at elaborating the cladiellin model to approach the cladiellin framework and discusses an unexpected but interesting Prins cyclisation/rearrangement process. Chapter 4 describes an enantioselective synthesis of batzelladine C methyl ester, permitting assignment of the relative and absolute stereochemistry of batzelladine C.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.584942  DOI: Not available
Share: