Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583821
Title: Design and synthesis of new potential drugs for the treatment of human African trypanosomiasis
Author: Baliani, Alessandro
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2006
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Abstract:
All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. In vitro toxicity against intact bloodstream form trypomastigotes of T. b. brucei and T. b. rhodesiense was also measured. Compound 6 and compound 54 showed IC 50 against T. b. rhodesience line of 25 nM and 18 nM respectively. Two compounds retained their trypanocidal effect in mice curing all the mice infected with a STIB 795 T. b. brucei model of infection. One compound cured also 1 mouse of 4 infected with the more stringent model STIB 900 T. b. rhodesiense . The comet assay showed that the compound is not genotoxic at the doses tested, indicating that this is a good drug lead against HAT.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.583821  DOI: Not available
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