Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578563
Title: PGC-1β regulates mitochondrial metabolic pathways in the gut-liver axis
Author: Bellafante, Elena
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2011
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Abstract:
ROS production is proportional to the increase in mitochondrial respiration and electron chain activity. Numerous factors (including radiations, oxygen shortage, carcinogens and inflammation) can give rise to ROS, ultimately leading to ROS- mediated genomic instability and cancer. Under normal conditions, the balance between ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressor, including enzymes such as superoxide dismutase, catalase, and those involved in glutathione metabolism. Some components of the ROS scavenging pathway are linked to mitochondrial oxidative metabolism by the PGC-l coactivators that enable cells to maintain normal redox status in response to changing oxidative capacity. The increase in mitochondrial number stimulated by these proteins could cause an increase in the production of ROS. Therefore, if ROS production were proportional to the increase of electron transport activity stimulated by the PGC-l proteins, these molecules would ultimately drive ROS levels higher. However, PGC-la is able to upgrade aerobic energy metabolism in tissues with high aerobic demand promoting ROS formation on one hand and ROS scavenging .systems on the other. Since the role of PGC-l ß in this process is completely unknown and ROS production is .commonly linked to mitochondrial dysfunctions that, in turn, are linked with several diseases, such as intestinal cancer and several metabolic diseases including steatohepatitis, we decided to investigate whether PGC-l ß could be involved in the mitochondrial homeostasis and ROS generation in two different organs, the intestine and the liver.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.578563  DOI: Not available
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