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Title: The role of ADAMTS-1, -4 and -5 in multiple sclerosis
Author: Gibrel, Gehan G. F.
Awarding Body: Sheffield Hallam University
Current Institution: Sheffield Hallam University
Date of Award: 2012
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ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs )-1, -4 and - 5 are secreted enzymes which are members of the glutamyl endopeptidases (GEPs) group of ADAMTSs. These enzymes break down chondroitin sulphate proteoglycans (CSPGs) which are key components of brain extracellular matrix (ECM). In multiple sclerosis (MS), CSPG breakdown by ADAMTSs may enable axonal regeneration or conversely it may lead to alterations of the ECM, allowing influx of inflammatory cells promoting tissue damage.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available