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Title: Non-traditional analgesics and the assessment of their efficacy in cats
Author: Murison, Pamela Jane
ISNI:       0000 0001 2417 939X
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2011
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Pain assessment in cats is difficult and although nociceptive testing is useful to compare analgesic drugs in a research setting, results may not equate to clinical efficacy. In addition, some traditional analgesic drugs may not be suitable for all animals. A new hand-held thermal nociceptive testing device was developed, tested in the laboratory and on human volunteers before preliminary developmental testing in cats. The use of the device was compared to an existing commercially available thermal nociceptive testing device in cats. Both devices were able to detect analgesia produced by buprenorphine. Using the new device, two doses of tramadol were compared to buprenorphine (as a positive control) and saline (a negative control) in a crossover designed study. Both doses of tramadol and buprenorphine produced anti-nociception with significant differences to the saline group. The two doses of tramadol were then used in cats undergoing ovariohysterectomy, where they were compared to pethidine. Assessments included thermal and mechanical nociceptive threshold testing at two sites as well as clinical assessments. Cats receiving tramadol 2 mg/kg were significantly less likely to require rescue analgesia than those in the pethidine group. Maropitant, an NK-l antagonist, was studied in healthy cats using mechanical and thermal nociceptive thresholds. Of the ten cats studied, five showed elevations of thermal threshold compared to baseline, indicative of an analgesic effect, although there was no statistical difference between groups in threshold values obtained. Maropitant, two doses of buprenorphine and a combination maropitantlbuprenorphine treatment were also studied in cats undergoing ovariohysterectomy. Thermal nociceptive thresholds at the wound edge were significantly higher in the group receiving maropitant, indicating the drug partially obtunds the development of thermal hypersensitivity. In conclusion, the new device performed effectively and enabled detection of differences in thermal hyperalgesia after surgery. Tramadol and maropitant may have utility as analgesics in cats.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available