Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568769
Title: Guanidine glycomimetics
Author: Jones , Iestyn Vernon
Awarding Body: Bangor University
Current Institution: Bangor University
Date of Award: 2012
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Abstract:
This thesis describes the investigation of methodologies towards the synthesis and purification of 5-, 6- and 7- membered guanidine heterocycles. Methods include intemlolecular epoxide ring opening reactions using guanidine and the intramolecular cyclization reactions of N-Boc-allylguanidines and N-Boc-homoallylguanidines in both epoxide ring opening reactions and palladium mediated cyclisations. The possible utility of these heterocycles as glycosidase inhibitors was investigated using enzymatic assays.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.568769  DOI: Not available
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