Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.567241
Title: Behavioural analysis of transgenic mice overexpressing gamma-synuclein
Author: Salem, Hatem
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
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Abstract:
The alpha-synucleinopathies is a diverse group of diseases characterised by malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common of all alpha-synucleinopathies. Intracellular inclusions, like Lewy bodies and certain other abnormal structures are the pathological hallmarks of this group of neurodegenerative diseases. The main protein component of these structures is alpha-synuclien. Alpha-synuclein is a member of the synuclein family, which consists of 3 closely related proteins, alpha-, beta- and gamma-synucleins. Alpha-synuclein is more extensively studied because of its direct involvement in human diseases, while our knowledge about two other family members is very limited. Neither beta-synuclein, nor gamma-synuclein is a component of Lewy bodies and other pathological structures typical for neurodegenerative diseases.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.567241  DOI: Not available
Keywords: QH301 Biology
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