Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566454
Title: Mathematical modelling of aortic dissection
Author: Li, Beibei
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2013
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Abstract:
An aortic dissection is a tear of the intima of the aortic wall that spreads into the media or between the media and adventitia. In addition to the original lumen for blood flow, the dissection creates a new flow channel, the `false' lumen that may cause the artery to narrow or even close over entirely. Aortic dissection is a medical emergency and can quickly lead to death. The mechanical property of the aorta has been described by the strain energy function given by Holzapfel et al. [2000]. The aorta is idealized as an elastic axisymmetric thickwalled tube with 3 layers. We focus on the dissection in media, which is considered as a composite reinforced by two families of fibres. We assume the dissection in the media is axisymmetric. The mathematical model for the dissection is presented. The 2D plane crack problem in linear elastic infinity plane and 2D strip, the axisymmetric crack problem in linear elastic compressible and incompressible tube, the axisymmetric crack problem in an incompressible axisymmetric aorta are applied to obtain solutions to three different problems. And the fluid flow inside the crack has been studied. The 2D plane crack problem in linear elastic infinity plane has been solved analytically. The 2D plane crack problem in linear elastic compressible and incompressible strip is modelled respectively and solved numerically. The models for axisymmetric crack problem in linear elastic compressible and incompressible tube are presented respectively. The numerical solutions for the crack problems are expressed, and the results are analyzed. The mathematical model of the incompressible aorta axisymmetric dissection is given, and the solutions are found numerically. The results change along with the different parameters in the strain energy function, which are analyzed and compared. The fluid flow inside the tear is assumed very thin which is expressed as the lubrication theory. We use the implicit method to model the Stokes equation numerically, and test the crack opening change along with time.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.566454  DOI: Not available
Keywords: QA Mathematics
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