Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557630
Title: Design, synthesis and evaluation of inhibitors against tumour-associated protease
Author: Hu, X.
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2012
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Abstract:
Proteases are a class of physiologically active proteins which lead different biochemistry reactions and are responsible to many physiology and pathology processes. Protease inhibitors therefore have emerged as potent therapeutic agents for various diseases. Successful examples include Cathepsin inhibitors and HIV aspartste protease inhibitors, while the matrix metalloproteinase inhibitors are deemed to be failure examples. In this thesis, a series of inhibitors of two distinct proteases seprase and proteasome were designed, synthesized and evaluated through different methods. The assessment of methodologies and clinical applications was also provided in guiding the future works.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.557630  DOI: Not available
Share: