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Title: The incidence and short-term outcome of Parkinson's disease and other Parkinsonian disorders in North-east Scotland : the PINE study
Author: Caslake, Robert
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2011
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Abstract:
A community-based, prospective study of the incidence of parkinsonism using multiple, overlapping recruitment methods was undertaken. From a base population of 311,770, followed over 3 years, 628 people were assessed. 293 were diagnosed with parkinsonism, of whom 53.2% had a baseline diagnosis of Parkinson’s disease (PD). 190 age and sex matched controls were also recruited. This cohort was combined with one recruited during a pilot study (83 patients) for calculation of incidence figures and follow-up, which will continue long-term. Using this combined cohort, age and sex specific incidence rates were calculated for parkinsonism (29/100,000/year) and PD (17.5/100,000/year). Incidence of both of these increased with age. PD was more common in men. Incidence did not vary by socioeconomic group. The results of the incidence study were compared with those found in an updated systematic review of incidence studies in PD. Mortality was compared between the control and patient groups at a median of 24 months follow-up. The adjusted hazard ratio for death compared with controls for patients with a clinical diagnosis of PD was 2.00 (95% CI 1.19-3.36) and for patients with causes of other parkinsonism was 3.36 (95% CI 1.93-5.84). Clinical diagnosis of the cause of parkinsonism changed over time, with most changes occurring within the first year. A validation study for the English language version of the PD-specific cognitive screening tool (the mini-mental Parkinson) used in this cohort was undertaken. A systematic review of the occurrence of psychotic features in PD, found 45 studies reporting median prevalence of hallucinations of 29.2%. The prevalence of hallucinations in this cohort was 5.5% at baseline and 16.7% at 3 years. Comparison of the results from this cohort with those of similar ongoing studies will give a greater understanding of the course of PD and allow more effective targeting of health-care resources.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.540482  DOI: Not available
Keywords: Parkinson's disease
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