Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540433
Title: Regulation of body weight : effects of pharmacological and environmental interventions on energy budget
Author: Zhang, Lina
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2011
Availability of Full Text:
Access through EThOS:
Full text unavailable from EThOS. Please try the link below.
Access through Institution:
Abstract:
Pharmacological blockade of the endocannabinoid system via rimonabant (SR141716) induced a sustained reduction in weight and fatness. Rimonabant-treated mice exhibited reduced metabolizable energy intake and increased daily energy expenditure on days 4-6 of treatment. However, these on the energy budget had disappeared by day 22-24. Rimonabant treatment increased daily physical activity levels throughout the study. These data suggested that rimonabant caused a negative energy balance by acting on both energy intake and expenditure. Melanin-concentrating receptor 1 (MCHR1) antagonism via GW803430 produced similar effects on energy  budget. However, only physical activity during the dark phase was increased by GW803430 treatment. MCHR1 antagonism produced a persistent anti-obesity effect and the initiation of weight loss resulted from a decrease in energy intake and an increase in active energy expenditure. With respect to environmental interventions, non-genetic individual variability in weightgain when fed a high fat diet (HFD) was investigated. I found that weight gain induced by HFD was associated positively with fat mass and fast free mass and negatively with physical activity prior to HFD exposure. Furthermore, fat mass and fat free mass were influenced by lactation litter size via weaning weight and post-weaning growth rate. Finally I used intermittent starvation to test whether the risk of starvation determines the lower intervention point as suggested by the dual intervention pointmodel. Overall, mice exhibited different behavioural and physiological responses to intermittent starvation dependent of the duration of treatment. This work contributes to a better understanding of the regulation of energy balance and provide useful insights for the prevention and treatment of obesity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.540433  DOI: Not available
Keywords: Obesity ; Body weight
Share: