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Title: Evaluation of vaccination in the UK paediatric population : reactogenicity, immunogenicity and consideration of epidemiological need to protect children and the wider population
Author: Southern, Jo
Awarding Body: The Manchester Metropolitan University
Current Institution: Manchester Metropolitan University
Date of Award: 2010
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Abstract:
Introduction Vaccination is accepted globally as the most effective preventative public health intervention against infectious disease. Rationalising vaccination schedules is key to ensuring optimal individual and population protection from potentially deadly diseases, with the most acceptable vaccines and schedules from economic and patient safety perspectives. Diseases for which vaccines are routinely recommended are identified through population level monitoring of cases and outcomes. Stringent assessment of vaccines in trials is required for licensure of novel products, usually with enhanced surveillance following introduction of a vaccination campaign to assess population impact and ongoing effectiveness. Method Testing novel vaccines with others that may be given concomitantly is not required for licensure. The UK Department of Health therefore commissions research to provide assurance that the addition of new vaccines is safe and does not compromise the existing routinely recommended schedule. A programme of trials recruiting infants and children was undertaken to provide such data. This body of published manuscripts describes trials that were undertaken for this purpose, to provide information both on novel antigens and novel delivery schedules. Data included in these manuscripts were provided to the Joint Committee for Vaccination and Immunisation (JCVI) to inform consideration of the addition of new antigens and or vaccines and refinement of existing schedules. Results: Studies described here contributed to the addition of meningococcal C conjugate vaccine to the programme and subsequent refinement of the schedule administered in early childhood; the addition of pneumococcal conjugate vaccine for infants; provided information for consideration about the use of conjugate booster campaigns in older children; the change to acellular pertussis and inactivated polio vaccine for infants and provided data to inform the future addition of pertussis vaccine for teenagers. Conclusion and impact: The information presented here would not have been available were it not for this Department of Health"funded programme of head to head comparison of products and evaluation of co-administration of products. Studies have contributed to the revision of the national schedule, which continues to be evaluated through further trials and routine surveillance activities.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.521029  DOI: Not available
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