Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514119
Title: Obesity and endothelial dysfunction : mechanisms, method development and interventions
Author: Cerri, Erika
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2010
Availability of Full Text:
Access from EThOS:
Access from Institution:
Abstract:
The principle aims of this thesis were to determine the effect of lowering plasma fatty acids (FA) on muscle microvascular blood volume (MBV) at rest and during exercise, investigate whether near-infrared spectroscopy (NIRS) can be used to measure muscle MBV in the obese, develop the contrast enhanced ultrasound (CEU) method in our laboratory for measuring muscle MBV of the human forearm, and use CEU to measure the MBV response to an oral glucose tolerance test (OGTT). No differences were observed in exercise-induced increases in MBV or resting MBV between control and low FA conditions created by niacin ingestion in lean and obese individuals. NIRS was not suited to measure muscle MBV in participants with a thick subcutaneous adipose tissue layer. The CEU method was successfully developed to measure MBV in the human forearm. CEU revealed a significant increase in MBV in response to an OGTT in lean trained individuals. This technique will be used in future studies to generate novel information on the suspected impaired MBV response after meal ingestion in obese individuals and to assess the effectiveness of interventions aimed at improving the MBV response and glycemic control to avoid the development of type II diabetes and cardiovascular disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.514119  DOI: Not available
Keywords: BF Psychology
Share: