Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512397
Title: Cardiovascular and respiratory reflex control systems in the regulation of pulmonary blood flow and ventilation during exercise
Author: Lykidis, Christos
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2010
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Abstract:
The regulation of pulmonary blood flow and ventilation during exercise is mediated by numerous factors, yet the role of certain cardiovascular and pulmonary reflex control systems is unknown. Therefore this thesis investigated the pulmonary vascular response to the activation of the muscle metaboreflex alone, and combined with activation of the muscle mechanoreflex. The ventilatory responses to the activation of the muscle metaboreflex were also studied under a background of activated ventilatory chemoreceptors. Finally the effect of increased metabolism on the ventilatory sensitivity to carbon dioxide was investigated in healthy humans. We found that activation of the muscle metaboreflex induced pulmonary vasoconstriction that was alleviated by muscle mechanoreflex activation. Furthermore a respiratory response to the activation of the muscle metaboreflex was observed in hypercapnia but not when breathing room air. Finally we found that increases in metabolic rate induced elevations in the ventilatory sensitivity to carbon dioxide. Overall these data suggest that the interplay between cardiovascular and respiratory control systems contribute to the regulation of pulmonary haemodynamics and breathing during exercise. Our findings could be implicated in the reduced exercise tolerance seen in chronic heart failure patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.512397  DOI: Not available
Keywords: RC1200 Sports Medicine ; QP Physiology
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