Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506239
Title: Pre-clinical evaluation of Bcl-2 inhibitor ABT-737 in small cell lung cancer
Author: Micha, Dimitra
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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Abstract:
The evasion of apoptosis is a common feature of various malignancies and often depends on the overexpression of Bcl-2 family antiapoptotic proteins. Resistance to chemotherapy and radiotherapy is promoted because these tumour cells have a higher threshold for apoptosis-promoting signals than their normal cell counterparts. This has lead to the development of BH3 mimetic compounds that target the survival proteins of the Bcl-2 family.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.506239  DOI: Not available
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