Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505582
Title: Iontophoretic delivery of selected antiparkinsonian agents in vitro
Author: Giller, Tomasz
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2009
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Abstract:
Pharmacological treatment of Parkinson's disease involves frequent dose adjustment, complex dose regimes. Also oral antiparkinsonian drugs suffer from the first pass effect, and a variable absorption in the gastrointestinal tract. The transdermal route is an advantageous alternative, as shown by the recent commercialization of a passive patch containing rotigotine (Neupro®). In this work, transdermal iontophoretic delivery of six drugs was performed, using side-by-side diffusion cells. The best candidates for iontophoretic delivery were pramipexole, selegiline, and piribedil. Trihexyphenidyl, entacapone and pergolide are poor candidates and probably would require patches of impractical size.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.505582  DOI: Not available
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