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Title: Regulation of the actin binding activity of basic calponin and its implication in cytokinesis
Author: Rozenblum, Tomas Guido
Awarding Body: The Open University
Current Institution: Open University
Date of Award: 2008
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Calponins (CaPs) are actin-binding proteins that stabilize actin filaments. Mammals express three genetic isoforms in a tissue-specific manner. CaPs share an N-terminal calponin-homology (CH) domain followed by short tandem sequence repeats termed calponin-like (CLIK ) repeats. The extreme C-termini of CaPs contain isoform-specific tail sequences. Basic calponin (hlCaP) was the first isoform to be discovered 22 years ago in an attempt to identify troponin-like proteins in smooth muscle. The scope of this thesis was to reveal the mechanisms that regulate the actin-binding activity of hlCaP.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available