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Title: Developing and characterising mucin films andevaluating them as a bacteria-resistant coating
Author: Bushnak, Ibraheem A.
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2008
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Mucin is a naturally occurring polymer that belongs to the glycoprotein family. It is an amphiphilic molecule made of two main parts: a hydrophobic protein backbone and hydrophilic carbohydrate side chains. As a result ofthis structure, it can adsorb on many types of surfaces to create a hydrophilic, lubricating layer. Mucin has been shown in recent studies to have the potential to suppress the adhesion of bacteria. The aim ofthis study is to develop a uniform mucin coating resistant to bacterial adhesion. In developing a coating technique, we created a multi-layer system consisting of a poly(acrylic acid) (PAA) copoly~er as a base layer and a mucin layer on top, as this exploits the mucoadhesion interactions between PAA and mucin in bonding to the base. The mucin coatings created were then evaluated against the adhesion of microorganisms, including two species of bacteria (Staphylococcus epidermidis and Escherichia cob) and one species of yeast (Candida albicans) known to be problematic for patients inserted with urinary catheters.
Supervisor: Not available Sponsor: Not available
Qualification Name: Not available Qualification Level: Doctoral
EThOS ID:  DOI: Not available