Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503417
Title: Developmental psychopathology in children with Williams Syndrome
Author: Chasouris, Antonios
Awarding Body: University of Glamorgan
Current Institution: University of South Wales
Date of Award: 2008
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Abstract:
Williams Syndrome (WS) is a genetic disorder that results in a wide variety of impairments, involving most of the areas of development. This thesis explores the differences in cognitive ability and attainment of developmental milestones in children with WS. Four experimental studies have been conducted involving 74 children between the ages of a few months to 18 years. Study 1 investigated the effect of deletion size in the cognitive ability of WS children, as this was measured by 4 different IQ tests. Study 2 examined the effect of deletion size in the attainment of developmental milestones, Study 3 examined the longitudinal course of IQ in children with WS and Study 4 examined a clinically observed do novo phenomenon of a strong leftward bias affecting attention and short term visuospatial memory. Studies 1 and 2 demonstrated an effect of deletion size on the cognitive abilities of children with WS. The greater the deletion size in the 7q11.23 area, the lower the performance on measures of cognitive ability and the longer and more problematic the attainment of developmental milestones. Study 3 indicated that there is a significant increase in the IQ scores of children with the typical deletion. The IQ scores remain however to the mild/moderate retardation - with average area of the IQ scale. Study 4 examined and tried to offer explanatory ideas in a de novo clinically observed phenomenon of a leftward bias affecting attention and visuospatial short term memory. Children with WS encountered great difficulty in detecting and remembering the position of items presented to the right side of a presentation matrix. Findings suggest deletion size has an influence on both performance on measures of cognitive ability and attainment of developmental milestones, the cognitive ability of children with WS significantly improves with advance of chronological age and that there is a leftwards bias affecting attention and short term visuospatial memory.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.503417  DOI: Not available
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