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Title: Determination of the ability of a recombinant protein to vaccinate against Leishmania mexicana and Leishmania donovani
Author: Basma, Doro
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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Leishmaniasis is a spectrum of diseases caused by protozoan parasites of the genus Leishmania. The disease affects the populations of 88 countries in the tropics and sub-tropics and causes three main types of disease, cutaneous leishmaniasis, mucocutaneous leishmaniasis and visceral disease. A vaccine to prevent infection is required, ideally one which can be given by a non-invasive route (e.g. orally) an can protect against more than one species of Leishmania. Previous studies have shown that subcutaneous vaccination L. donovani y-GCS (gamma-glutamyl cyst synthetase) protein protected against L donovani infection. Therefore in this study the ability of the same vaccine to protect against L mexicana infection was determined, where mice were immunised with protein alone or protein incorporated into a non-ionic surfactant vesicles (NIV) delivery system. In addition the ability of oral vaccination with y-GCS protein alone or incorporated into two different delivery systems (NIV or Bilosomes) to protect against L. donovani was determined.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available