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Title: Role of mast cells in ischaemic stroke
Author: Shende, Vishvesh H.
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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The purpose of the project was to investigate the role of mast cells and oestrogen in ischaemic stroke. Inflammatory cells and mediators may prove to be novel targets for stroke. In addition studies carried out on animals clearly signify that biological and endogenous sex steroids play a role in experimental stroke outcome. Histological staining (toluidine blue) of coronal sections from SHRSP and WKY rats post-middle cerebral artery occlusion (MCAO, an experimental stroke model) was used to observe cerebral mast cells and their anatomical localisation. Mast cells were found in the brain at 2 hours, 24 hours, 8 days and 30 days post-MCAO in the SHRSP with the peak levels at the earlier time points. The majority of mast cells were localised in thalamic and hippocampus regions. Mast cells were also seen in cortex region, a region within the MCA territory.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available