Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502317
Title: Effects of IGF-1, IGFBP-5 and TGFB1 on cell proliferation, attachment and migration in mammary epithelial and mesenchymal cells
Author: Ahwaide, Hoda S.
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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Abstract:
Insulin-like Growth Factors (IGFs) are a determining factor in breast cancer development since high circulating concentrations of IGF-I are associated, in previous epidemiological studies, with an increased risk of breast cancer. The actions of IGF-I, which plays an important survival role for several cell types and protect cells from apoptosis, is modulated by a family of IG; proteins (IGFBPs) IGFBP-5 has been proposed to induce cell death of epithelial and mesenchymal cells, but, failed to enhance mammary epithelial cell attachment. This research initially examined the effects of growth factors on mammary cell survival and attachment. IGF-I was consistently the best survival and proliferative factor tested for epithelial and mesenchymal cells, but, failed to enhance mammary epithelilial cell attachment. This research initially examined the effects of growth factors on mammary cell survival and attachment. IGF-I was consistently the best survival and proliferative factor tested for epithelial and mesenchymal cells, but, failed to mammary epithelial cell altachment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.502317  DOI: Not available
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