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Title: The effect and interactions of the minor groove binders AIK 19/56/2 and AIK 20/25/1 on bacterial, fungal and mammalian cells
Author: Imtiaz, Nashmya
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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Minor Groove Binders are a group of compound that bind to the minor grooves of DNA. Some of these compounds are able to bind to specific sequences on DNA, causing toxicity to cells, and this has generated an interest in their use as antimicrobial or anticancer agents. They are generally characterised by their recognisable crescent shape. The focus of this research is the effect of two minor groove binders AIK 19/56/2 and AIK 20/25/1 on the survival of various bacterial cell types as well as mammalian and fungal cells. This has been examined using growth curves, killing curves, fluorescent microscopy, HPLC spectra and topoisomerase I inhibition have been used. These experiments have given an insight into the mechanism of action of these compounds.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available