Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502306
Title: In-vitro evaluation of a lyophilised nasal dosage system containing chlorhexidine
Author: Yan, Jing
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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Abstract:
The aim of this research project was to examine the in-vitro properties of a nasal insert formed from a lyophilised viscous hydroxyproylmethylcellulose (HPMC) gel solution designed to deliver chlorhexidine intranasally to prevent MRSA colonisation. In-vitro drug release tests indicated that the chlorhexidine release rate is influenced by the molecular weight and concentration of HPMC and the presence of mannitol. Increasing the HPMC molecular weight and concentration made it more difficult for the drug to release from the matrix and reduced the release rate; as there could be more HPMC molecules in unit volume which means more polymer matrix. Adding mannitol resulted in faster release of chlorhexidine, as mannitol dissolves in water and creates niore pathways for the drug to diffuse through. In-vitro dynamic adhesion tests were carried out on an agar/mucin plate which was designed to mimic the movement of the formulation over the nasal mucosa. Results indicated that increasing the HPMC molecular weight and concentration increased adhesion to this synthetic mucosal surface.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.502306  DOI: Not available
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