Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502269
Title: The effect of hypoxia and the transcription factor hypoxia inducible factor-1 (HIF-1) on metastasis
Author: Knight, Laura K.
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Abstract:
Tumour hypoxia has been widely implicated in the development of aggressive, therapy resistant malignant disease. Patients presenting with more hypoxic tumours experience higher levels of mortality compared to those with lower levels of hypoxia. The primary reason or this increased phenotype is the stabilisation of the transcription factor hypoxia inducible factor-1 (HIF-1). Upon exposure to hypoxic conditions, the alpha subunit of this heterodimer Stabilised and binds to the beta subunit. Once stabilised HIF-1 induces gene expression resulting in the Increased exproression of a number of proteins that confer advantages onto tumour cells. Areas such as angiogenesis, glucose metabolism, invasion and metastasis are tumour cells. Areas such as angiogenesis, glucose metabolism, invasion and metastasis are widely influenced in this way. In the following studies, the role of HIF-1 in the development of metastatic disease was examined.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.502269  DOI: Not available
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