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Title: Engineering and functional characterisation of pentameric concantenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors
Author: Carbone, Anna Lisa
Awarding Body: Oxford Brookes University
Current Institution: Oxford Brookes University
Date of Award: 2009
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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that influence neurotransmitter release, hence constituting a key component of the physiological mechanisms of neuronal signalling. This thesis is concerned with the properties of the α4β2 nAChR, the most abundant nAChR in the brain, and the major contributor to the central effects of nicotine. The α4β2 nAChR is made up of five subunits, which in heterologous systems can assemble into at least two different stoichiometrics: the high sensitivity (HS) (α4)2(β2)3 stoichiometry and the low sensitivity (LS) (α4)3(β2)2 stoichiometry, which might both exist in native tissues. Despite the attractiveness of the α4β2 nAChR as a target for therapeutic intervention, progress in the development of α4β2 nAChR-selective drugs has been slowed, partly because of the lack of stoichiometric specific receptor models.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available