Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501593
Title: Chemical and molecular markers of hepatic drug bioactivation, apoptosis and necrosis
Author: Antoine, Daniel James
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2009
Availability of Full Text:
Access through EThOS:
Abstract:
Hepatotoxicity represents one of the most prevalent drug-induced adverse effects seen in the clinic and is a major cause of attrition of new chemical entities in development. Some adverse drug reactions are associated with metabolic activation to a chemically reactive intermediate. The hepatotoxicity associated with acetaminophen (APAP; paracetamol) and furosemide (FS) in mice is initiated by the formation of a reactive metabolite which has been well characterised. APAP hepatotoxicity is a major clinical problem, and with FS represents an important tool to investigate mechanisms of drug induced liver injury (DILI) in animal models.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.501593  DOI: Not available
Share: