Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501326
Title: Molecular analysis of iron-storage in Escherichia coli
Author: Batley, Charlotte
Awarding Body: The University of Reading
Current Institution: University of Reading
Date of Award: 2008
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Abstract:
Cellular iron is stored within protein molecules generically called 'ferritins'. Such iron-storage molecules are composed of either 12 or 24 structurally identical subunits that form a spherical shell around a central storage cavity with the capacity to accept 500-4,500 h-on atoms in the form core E. coli contains four ferriritin-like proteins, FtnA, Bfr, Dps and FtnB, the latter of which is yet to be characterised. A bacterial-2-hybrid approach was used to investigate interactions of E. coli FtnA, Bfr, FtnB and Bfd proteins with each other, and of Bfr with other E. coli proteins expressed from a random E. coli gene-fusion library. Bfr-Bfr and FtnA-FtnA interactions were confirmed, but contrary to expectation, no FtnB-FtnB or Bfr-Bfd interaction could be identified.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.501326  DOI: Not available
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