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Title: Studying protein interactions of a bacterial type II polyketide synthase
Author: Castaldo, Gaetano
Awarding Body: University of London
Current Institution: University College London (University of London)
Date of Award: 2008
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Daunorubicin (DNR) and its C-14 hydroxylaled derivative doxorubicin (DXR) a are the most widely used anthracyclines as anti-tumour agents. DNR and DXR are produced by the soil bacteria Streptomyces peucetius through a biosynthetic pathway that employs a type II polyketide synthase (PKS). Type II PKSs consist of several discrete, monofunctional proteins that form a dissociable complex. Studies on enzyme complex formation and substrate channelling are essential for a better understanding of metabolism and could lead to the generation of novel compounds by 'combinatorial' biosynthesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available