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Title: Functional analyses of novel insect virus IRES elements
Author: Groppelli, Elisabetta
Awarding Body: Surrey University
Current Institution: University of Surrey
Date of Award: 2007
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Rhopalosiphum padi virus (RhPV) is a member of the Dicistroviridae. The genomes of these viruses contain two open reading frames, each preceded by distinct internal ribosome entry site (IRES) elements. The activity of the RhPV 5' IRES element has previously been demonstrated in mammalian, insect and plant translation systems. It has also been shown that the RhPV 5' IRES forms 48S initiation complexes in vitro with just the mammalian initiation factors eIF2, eIF3 and elFl. It is also possible to delete large regions of the 5' IRES without affecting initiation complex formation. We have now defined the minimal sequences required for directing internal initiation in mammalian, plant and insect translation systems.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available