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Title: Nutri-epigenomic investigation into the effect of selenium on prostate cancer
Author: Bekaert, Bram
Awarding Body: Surrey University
Current Institution: University of Surrey
Date of Award: 2008
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Selenium (Se) is an essential trace element that has a role in cancer chemoprevention. DNA methylation is an important factor in carcinogenesis and one-carbon metabolism may influence this by providing methyl groups for DNA methylation. In previous studies Se was shown to be inversely correlated with homocysteine (Hcy), a product of one-carbon metabolism, in humans but it is unclear whether Se has a direct effect on DNA methylation. The relationship between Se and one-carbon metabolism was therefore investigated on two levels: (i) an investigation into the effect of Se supplementation on nutritional factors involved in one-carbon metabolism and (ii) an integrative epigenomic analysis using prostate cell lines and tissues to determine the effect of Se supplementation on DNA methylation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available