Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499371
Title: Mucoadhesion of chitosan and derivatives : from mechanism to dosage form design : understanding of chitosan solubility parameters, interactions with mucosal membranes and BCS class II drugs in formulations, targeting enhanced permeation and increased bioavailability of poorly absorbable drugs
Author: Sogias, Ioannis Andrea
Awarding Body: Reading University
Current Institution: University of Reading
Date of Award: 2009
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Abstract:
Chitosan is a natural polysaccharide produced commercially from chitin by partial deacetylation. It consists of glucosamine and Al-acetyl glucosamine units chained through glycosidic bonds. Due to the biocompatible and mucoadhesive profile it presents, it has attracted considerable attention for potential uses in pharmaceutics. However, the limited solubility of chitosan only in acidic solutions constrains some of its possible uses in biological applications. Thus, the synthesis of chitosan derivatives with broader solubility and increased functionality has been considered as a strategy to extend chitosan uses.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.499371  DOI: Not available
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