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Title: Pericellular matrix (PCM) influences the biological response of individual chondrocytes to microcompression
Author: Wang, Qi Guang
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 2009
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A chondrocyte produces a hydrated pericellular matrix (PCM); together they form a chondron. Previous work has shown that the presence of the PCM influences the biological response of chondrocytes to loading. The objective of this study was to microcompress single chondrocytes and chondrons to determine their biological responses to mechanical stimulation. To address this, chondrocytes and chondrons were enzymatically isolated from bovine articular cartilage and characterised using a series of biochemical assays. Glycosaminoglycans of the PCM were quantitied using a novel technique; fluorophoreassisted carbohydrate electrophoresis (FACE) and the data were compared with immunofluorescence.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available