Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499117
Title: The epidemiology of Campylobacter jejuni and Campylobacter coli in north east Scotland
Author: Gormley, Fraser James
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2008
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Abstract:
This epidemiological investigation focussed on Campylobacter jejuni and Campylobacter coli in the north east of Scotland (Grampian). Scotland, in 2007, had an annual incidence of 101.5 cases/100,000 people, while in Grampian this figure was 120/100,000.  C. jejuni and C. coli are ubiquitous and are natural commensals of a range of animals, therefore understanding the epidemiology of these organisms involves identifying their putative sources and monitoring their dynamics in such hosts.  In this study, the use of various epidemiological tools showed that humans are infected from different sources and notably by chicken. Between 2001 and 2006, the population structure of Campylobacter in retail chicken changed  more than in humans, as shown by characterisation by Multilocus sequence typing (MLST).  There was however a high degree of overlap between these respective strains suggesting that chickens are a major source of human infection.  Furthermore, comparison of the same strains using antimicrobial resistance profiles revealed the same commonality of strains. Infection in the high risk 0-4 year old age group was shown to be attributable mainly to chicken in an urban environment but more attributable to cattle in rural areas.  This may reflect relative rates of exposure to these important sources of Campylobacter. Characterisation of a large outbreak in north east Scotland using various typing techniques identified chicken liver paté as a vehicle for C. jejuni infection; multiple strains were identified in the food and more than one patient displayed co-infection with different strains. These investigations have provided useful information which contributes to the overall surveillance of human campylobacteriosis and the epidemiology of Campylobacter in different hosts.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.499117  DOI: Not available
Keywords: Campylobacter jejuni ; Campylobacter Infections ; Campylobacter infections in poultry
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